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Management of Cancers including Surgical Treatment, Chemotherapy & Radiotherapy
After comprehensive assessment, a treatment plan is formulated according to patient's conditions. The treatment of choice would be modified according to the histological cell type and gradings of the tumour.
Cervical Cancer
- Stage 1a1 disease is the earliest stage, which could be treated with a simple hysterectomy or a local excision, e.g. large loop excision of the transformation zone or cone biopsy, depending on individual condition.
- Stage 1b1 and early 2a1 diseases have to be treated with radical hysterectomy and bilateral pelvic lymph node dissection. Most of the operations can be performed laparoscopically with/without the assistance of the robotic surgical system, i.e. da Vinci Surgical System.
- Locally advanced diseases would be treated with chemoradiation or radiotherapy.
- Chemotherapy may be the treatment of choice if the disease has metastasised outside the pelvis.
Ovarian Cancer
Early-stage disease
- In some of the patients, the diagnosis of ovarian cancer cannot be confirmed before operation. Therefore, surgical removal and histological confirmation is usually the first step to take.
- The standard treatment for ovarian cancer should be the removal of uterus, both tubes and ovaries together with comprehensive staging operation, which could be performed by laparotomy or laparoscopy depending on individual’s situation.
- For patients who are young and want to retain fertility, fertility sparing operation can be considered for suitable cases with favourable histological types and gradings.
- Most patients require adjuvant chemotherapy.
Late-stage disease
- Primary debulking operation followed by chemotherapy is the treatment of choice. But, if an optimal debulking is unlikely to be achieved, neoadjuvant chemotherapy should be considered.
Endometrial cancer
- Surgery is the mainstay of treatment.
- The mode of operation depends on the histological cell types, grading and the extent of tumour involvement in the uterus.
- Most of the operation could be done laparoscopically with/without robotic assistance.
- Patient may require radiotherapy or chemotherapy after operation.
Vulval cancer
- Surgery is the mainstay of treatment.
- Radical excision of vulval lesion with/without bilateral groin node dissection is the most commonly performed operation.
- Post-operative radiotherapy is indicated in selected cases.
- For locally advanced diseases, patient may benefit from pre-operative radiotherapy or chemoradiation.
Vaginal cancer
- Surgical treatment is adopted in selected cases only.
- Chemoradiation or radiotherapy is the treatment of choice if patients are not suitable for surgical removal.
Cancer of the fallopian tube and peritoneum
- The treatments of fallopian tube cancer and peritoneal cancer are similar to that of ovarian cancer.
- Most of the patients with peritoneal cancer present with widespread peritoneal disease instead of a pelvic tumour.
Gestational trophoblastic neoplasia
- Chemotherapy is the mainstay of treatment.
- Single agent chemotherapy is for low-risk patients and combination chemotherapy for high-risk patients.
- Surgical resection is indicated only in selected patients, especially those with chemoresistant diseases.